reverse transcriptase

A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

reverse transcriptase

(trænˈskrɪpteɪz)

(Biochemistry) an enzyme present in retroviruses that copies RNA into DNA, thus reversing the usual flow of genetic information in which DNA is copied into RNA

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

reverse′ tran•scrip′tase

(trænˈskrɪp teɪs, -teɪz)
n.

a retrovirus enzyme that synthesizes DNA from viral RNA, the reverse of the usual DNA-to-RNA replication: used in genetic engineering.

[1970–75]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

reverse transcriptase - a polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses

polymerase - an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA

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References in periodicals archive

He would also like to develop a new reverse transcriptase inhibitor specifically for the L1 reverse transcriptase.

HIV drug could treat Alzheimer's finds new study

The SVM technique was adequate to produce an effective QSAR model and outperformed those in the literature and the predictive stages for the inhibitory activity of reverse transcriptase by HEPT derivatives.

A nonlinear QSAR Study Using Oscillating Search and SVM as an Efficient Algorithm to Model the Inhibition of Reverse Transcriptase by HEPT Derivatives

Results: For all patients, no significant difference was found in mRNA expressions of human telomerase reverse transcriptase and dyskerin (p>0.05), although their levels in tumour tissues were found to be higher than in normal tissues.

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer

We compared the telomere length and telomerase activity in DPaSCs with those in MSCs and found that DPaSCs possessed ideal characteristics on telomere length, telomerase activity and reverse transcriptase activity, making DPaSCs suitable alternative candidates for regenerative medicine."

Human dental cells analyzed for telomere length, telomerase activity

Efavirenz is the non-nucleoside reverse transcriptase inhibitor of choice with rifampicin.

Pharmacokinetic interactions between antiretrovirals and rifampicin-based tuberculosis treatment

In particular, the recent use of the nucleos(t)ide reverse transcriptase inhibitors abacavir and didanosine has been associated with myocardial infarction in the large DAD study cohort [1].

Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients

The group conducted a study, published recently in the New England Journal of Medicine, that investigated the association of cumulative exposure to protease inhibitors and non-nucleoside reverse transcriptase inhibitors with the risk of myocardial infarction.

Class of antiretroviral and risk of myocardial infarction

The survey, which looked at specimens from 3,130 newly diagnosed, drug-naive individuals, found that 4% of infections had mutations conferring resistance to nucleoside reverse transcriptase inhibitors, 7% to nonnucleoside reverse transcriptase inhibitors, and 2% to protease inhibitors.

Nationwide survey says 10% of HIV is resistant

Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV treatment regimens are better at suppressing the virus than protease inhibitor (PI) regimens.

Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV treatment regimens are better at suppressing the virus than protease inhibitor (PI) regimens

Identify the primary functions of each of the following viral proteins: gp120, gp41, reverse transcriptase, integrase, protease.

Continuing education questions: Fall 2006