(17,18) HepPar-1 positivity is useful in differentiating FLC with pseudoglandular pattern from intrahepatic cholangiocarcinoma and scirrhous HCC, both of which are mostly negative for HepPar-1.
In the latter case, multiple and deep biopsies are recommended for the diagnosis because sometimes the scirrhous and fibrotic reaction can invade the gastric wall without mucosal involvement.
Several complications following castration have been recorded by several researchers like pyocele (Sagar et al., 2010) hydrocele (Kamalakar et al., 2014) and scirrhous cord (Kamalakar et al., 2015).
Sowa, "Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis," British Journal of Cancer, vol.
Immunohistochemical staining was not performed, and the mass was deemed most consistent with a carcinoma of hepatic origin accompanied by an overwhelming scirrhous response; however, a nonneoplastic inflammatory process could not be ruled out.
The diagnostic failure of the FNAC procedure in some cases can be attributed to unsatisfactory and nonrepresentative aspirates, especially in smaller lesions and in tumours with low cellularity like scirrhous carcinoma.
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