severe combined immunodeficiency

n. Abbr. SCID

Any of various, potentially fatal genetic disorders of the immune system marked by the absence of T cells, by inadequate B-cell function, and in some forms by the absence of B cells and natural killer cells, resulting in the body's inability to resist infection.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

severe combined immunodeficiency

(SCID) A birth defect in which babies lack sufficient T-cells and B-cells (white blood cells). These cells are vital to the working of the immune system. Sufferers have little or no protection against disease.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

severe combined immunodeficiency - a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

SCID, severe combined immunodeficiency disease

immunodeficiency - immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced

monogenic disease, monogenic disorder - an inherited disease controlled by a single pair of genes

ADA-SCID - SCID resulting from mutation of a gene that codes for adenosine deaminase

X-linked SCID, X-SCID - SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor

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References in periodicals archive

Cytegrity stable producer cell line will be used to produce the viral vector for Mustang Bio's MB-107 lentiviral gene therapy program for the treatment of X-linked severe combined immunodeficiency (XSCID).

Mustang Bio Announces License Agreement with CSL Behring for the Cytegrity Stable Producer Cell Line for the Production of MB-107 Lentiviral Gene Therapy

Adagen Injection is a modified enzyme used for enzyme replacement therapy for the treatment of severe combined immunodeficiency.

Adagen Market Report Overview, Market Share by Manufacturers, Concentration Ratio and Forecast to 20

For a few conditions, evaluations to measure TRECs are usually conducted in clinical practice (5): i) newborn screening tests for severe combined immunodeficiency (SCID), ii) evaluation of immune reconstitution during antiretroviral therapy in AIDS patients, and iii) testing T cell reconstitution after bone marrow transplantation.

T cell receptor excision circles as a tool for evaluating thymic function in young children

Mona Dash's debut memoir, A Roll of the Dice, is an odyssey of an invincible mother who, despite her best efforts, loses her firstborn son diagnosed with SCID (severe combined immunodeficiency).

Mona Dash: A Roll of the Dice

X-linked severe combined immunodeficiency (SCID-X1) is a genetic disorder that is caused by mutations of a single gene, ILR2G.

Sirion Biotech Licenses Technology to National Institute of Allergy and Infectious Diseases to Boost Clinical Efficacy of Lentivector Gene Therapy for X-Linked SCID

He was diagnosed with Severe Combined Immunodeficiency (SCID), a potentially fatal primary immunodeficiency, a few weeks after he was born.

Little boys in Bubble facing a fight for life; FAMILIES SHARE THEIR STORIES OF HEARTACHE AND HOPE

Eight infants with the disorder, called X-linked severe combined immunodeficiency (X-SCID), received an experimental gene therapy co-developed by National Institutes of Health scientists.

Gene Therapy Restores Immunity in Infants

Omarion Jordan, who turns 1 later this month, had the therapy in December to treat severe combined immunodeficiency syndrome, or SCID.

Doctors use HIV in gene therapy to fix immune disorder

US scientists say they used HIV to make a gene therapy that cured eight infants of severe combined immunodeficiency, or "bubble boy" disease, BBC reports.

HIV used to cure 'bubble boy' disease

The results of these studies, including a recently published article that showed the antibody treatment was safe in non-human primates, set the stage for a clinical trial of the antibody at Stanford and the University of California-San Francisco in children with an immune disorder called severe combined immunodeficiency.

Antibody Could Increase Cure Rate For Blood, Immune Disorders