simvastatin

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sim·va·stat·in

 (sĭm′və-stăt′n)
n.
A statin drug, C25H38O5, that blocks the body's synthesis of cholesterol and is used to lower cholesterol (especially LDL) levels and to reduce the risk of heart attack and stroke in individuals with elevated risk.
[sim- (perhaps alteration of syn-, pref. indicating attachment on the same side of the plane as a double bond; see syn-) + -vastatin, statin suffix; see pravastatin.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.simvastatin - an oral lipid-lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks
Zocor
lipid-lowering medication, lipid-lowering medicine, statin, statin drug - a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

simvastatin

n simvastatina
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
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References in periodicals archive
6, 2019 (HealthDay News) -- Among patients hospitalized for acute coronary syndrome (ACS), the greatest benefit from simvastatin-ezetimibe compared with simvastatin alone to lower lipid levels was observed in those 75 years of age or older, according to a study published online July 17 in JAMA Cardiology.
High-Intensity Lipid Lowering May Aid Very Elderly After ACS; Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years
Simvastatin, among others, is one of the drugs readily available to the public for cholesterol problems.
Effect of Ehretia microphylla on the blood cholesterol and weight of ICR mice (Mus musculus)
The method, which we call CypCel is based on a drug biomarker simvastatin, a cholesterol reducing medication, that has the unusual property of being highly metabolised in the small intestine by the enzyme CYP3A4, which is expressed on the villi.
ImmunogenX Completes CypCel Trial for Celiac Disease
This study aimed to explore the roles of simvastatin on ox-LDL-induced ER stress and apoptosis in endothelial cells.
Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells
(5) reported that simvastatin, compared to other statins, is more suitable for the prevention of neurodegenerative conditions because of its high capacity to penetrate the blood-brain barrier, strong cholesterol lowering effect on neurons, and protection against neural cell death.
The Effects of Simvastatin on Experimental Schizophrenia Models in Mice
Now a study has shown that the combination of ezetimibe plus simvastatin (Vytorin) reduces the risk of a future ischemic stroke in patients who had suffered a stroke prior to their ACS episode.
Adding a Second Cholesterol-Lowering Agent Reduces the Likelihood of Recurrent Stroke
Simvastatin shows gainful effect for ischemic stroke by upregulation of eNOS activity [14].
Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial
We recently reported protective and therapeutic effects of Crataegus aronia extracts on NAFLD in animal models (Al Humayed 2016), and here we investigated the ultrastructural changes in hepatocytes upon induction of hepatic steatosis in rats fed on a high fat diet using transmission electron microscopy (TEM) and compared the effects of Crataegus aronia and simvastatin on restoring the architecture of liver cells distorted by the disease.
Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis/ Efectos Terapeuticos Diferenciales de Crataegus aronia y Simvastatina sobre la Estructura del Hepatocito en la Esteatosis Hepatica
UK researchers have begun a GBP6m clinical trial set to investigate the potential of simvastatin in the treatment of multiple sclerosis, Pharma Times reported on Tuesday.
UK researchers begin Phase III trial to investigate statin's potential in MS treatment
Objective: To evaluate the effect of azithromycin in combination with simvastatin in the treatment of chronic obstructive pulmonary disease (COPD) complicated by pulmonary arterial hypertension.
Effect of azithromycin in combination with simvastatin in the treatment of chronic obstructive pulmonary disease complicated by pulmonary arterial hypertension
The first group is given aqua dest only, the second group is given simvastatin only, the third group is given simvastatin and soursop leaves extract, the fourth group is treated with 96% ethanol extract from 5% soursop leaves extract, the fifth group is treated with 96% ethanol extract from 15% soursop leaves extract, and the sixth group is treated with 96% ethanol extract from 25% soursop leaves extract.
SOURSOP LEAVES FOR REDUCING BLOOD CHOLESTEROL LEVEL IN WHITE MALE RATS (RATTUS NOVERGICUS)
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