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Once Cas12a encounters a target DNA sequence, also called a trigger, it cleaves the double-stranded DNA and transforms into an enzyme that can slice any single-stranded DNA it encounters.

MIT - Using CRISPR to program gels with new functions

Plasma DNA might display signs of DNA damage with 5' or 3' overhangs or single-stranded nicks mediated by DNase1 or other DNA-hydrolyzing enzymes (3).

DNasel Does Not Appear to Play a Major Role in the Fragmentation of Plasma DNA in a Knockout Mouse Model

Dubbed 'single-stranded origami,' their new strategy uses one long, thin noodle-like strand of DNA, or its chemical cousin RNA, that can self-fold -- without even a single knot -- into the largest, most complex structures to date.

Spaghetti-Like, DNA 'Noodle Origami' New Shape of Things to Come for Nanotechnology

"Ionis has made significant breakthroughs showing that chemically modified single-stranded oligonucleotides can activate the RNAi pathway.

Ionis, Suzhou

20 mg single-stranded herringbone DNA was mixed into the magnetic fluid.

INVESTIGATION OF DNA-MAGNETIC NANOPARTICLE INTERACTION BY MAGNETO-OPTICAL LINEAR DICHROISM

Later, many other examples emerged, showing that single-stranded DNAs and RNAs are capable to form complicated 3D structures, which allows them to specifically bind certain targets and even directly catalyze certain reactions.

Systematic comparison of the capability of modified nucleoside triphosphates to act as a substrate for thermostable DNA polymerases during PCR

In order for these specific primers to anneal, the template material must be single-stranded (ssDNA).

Alternative nucleic amplification strategies, part 2: LCA and HDA

Presently, Smarticles is in clinical development delivering both a single-stranded and a double-stranded oligonucleotide through licensees ProNAi Therapeutics and Mirna Therapeutics, respectively.

Marina Biotech receives patent for Smarticles

The protein complex Replication factor A (Rfa) is a single-stranded DNA binding known to be involved in DNA replication, repair, recombination and cell cycle regulation (1).

The characterization of Rfa interaction with Csm3, Mrc1, and Tof1

Measles is caused by the measles virus, a single-stranded, negative-sense enveloped RNA virus of the genus Morbillivirus within the family Paramyxoviridae.

Measles claims first death in Lahore