spi·ro·no·lac·tone

(spī′rə-nō-lăk′tōn, spī-rō′-, spī-rŏn′ə-)

An aldosterone antagonist and antiandrogen, C₂₄H₃₂O₄S, that promotes diuresis and is used to treat fluid retention, androgenic syndromes in women, and hypertension.

[Alteration of spirolactone : Latin spīra, coil; see spiral + lactone.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

spironolactone

(ˌspaɪrənəʊˈlæktəʊn)

(Pharmacology) a diuretic that increases water loss from the kidneys and is much used to treat oedema in heart and kidney failure

[C20: from spiro-² + linking syllable -no- + lactone]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

spironolactone - a synthetic corticosteroid (trade name Aldactone) used to treat hypertension

Aldactone

antihypertensive, antihypertensive drug - a drug that reduces high blood pressure

adrenal cortical steroid, corticoid, corticosteroid - a steroid hormone produced by the adrenal cortex or synthesized; administered as drugs they reduce swelling and decrease the body's immune response; "adrenal cortical steroids are used to treat many different conditions"

Translations

spironolactone

n espironolactona

Mentioned in

References in periodicals archive

Patients who were excluded from GISSI-HF were older and more often female; had higher BMI, systolic blood pressure, and NYHA class; and more rarely used ACE-Is, [beta]-blockers, and spironolactone (see online Supplemental Table 3).

Interaction of galectin-3 concentrations with the treatment effects of [beta]-blockers and RAS blockade in patients with systolic heart failure: a derivation-validation study from TIME-CHF and GISSI-HF

Importantly, patients will still need to continue their other heart medications, such as beta-blockers (e.g., metoprolol and carvedilol) and aldosterone blockers (e.g., spironolactone).

Life-saving new medication for heart failure patients

The dog was treated with Propanolol @) 0.2 mg/ kg twice daily, Digoxin @ 0.25 mg daily PO, Spironolactone @ 1mg/kg twice daily and Enalapril @ 0.25 mg/kg twice daily for 7 days.

Diagnosis and therapeutic management of atrial fibrillation in a dog

Spironolactone, usually used for high blood pressure and heart failure, could help people suffering from osteoarthritis.

Health news

In this paper in the British Medical Journal the authors report on a study that investigates whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years of age.

Spironolactone and the risk of breast cancer in women

In the United States, spironolactone is the only antiandrogen treatment option.

When to consider PCOS in female acne patients

The patient had a history of diabetes mellitus and liver cirrhosis with ascites; he had been taking a potassium-holding diuretic, spironolactone, for 8 months.

Spironolactone-induced gynecomastia

For starters, Amneal Pharmaceuticals LLC has received a green light from the FDA to manufacture spironolactone HCI tablets in 25-, 50- and 100-mg strengths.

The pipeline continues to be productive

Use of renin -angiotensin-aldosterone system blockers (angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and spironolactone) and their association with postoperative AF (AF episode lasting > 5 min) were evaluated.

Association between renin-angiotensin-aldosterone system blockers and postoperative atrial fibrillation in patients with mild and moderate left ventricular dysfunction/Hafif ve orta derecede sol ventrikul disfonksiyonu olan hastalarda renin-anjiyotensin-aldosteron sistem blokerleri ile kalp cerrahisi sonrasi gelisen atrial fibrilasyon arasindaki iliski

Aldosterone antagonists, which include spironolactone, work by inhibiting sodium resorption in the kidneys and interfering with the sodium-potassium exchange in the blood.

Heart failure drugs underprescribed: aldosterone antagonists are typically used in conjunction with other medications

He reported on 64 inpatients and outpatients with major depression who were placed on escitalopram (Lexapro) at 10-20 mg/day and randomized 2:2:1 to 3 weeks of double-blind fludrocortisone at 0.2 mg/day, spironolactone at 100 mg/day, or placebo.

Fludrocortisone as add-on may boost onset of SSRI

For patients who are allergic to sulfa-containing diuretics, doctors sometimes prescribe triamterene, spironolactone, amiloride, or ethacrynic acid.

Allergic to sulfa