Local anesthetics are known to cause vasodilatation by increasing capillary permeability with anti-inflammatory, antimicrobial, and sympatholytic effects.
Dexmedetomidine (DEX), a selective agonist of [[alpha].sub.2]-adrenergic receptors, has sedative, analgesic, and sympatholytic properties, and it has been used for analgesia, sedation, and anesthetic sparing.
These investigations were conflicting in techniques and results, particularly with respect to the rate and seriousness of RAS1.8 Different method utilized to get relieve from RAS consists of utilizing injections of vasodilators and lidocaine (nitroglycerine, calcium channel blockers) within arteries, sympatholytic blocks i.e.
May cause bradycardia and hypotension due to sympatholytic effects Ketorolac Acetic acid that nonselectively inhibits cyclooxygenase, anti-inflammatory.
(16,17) Heat exposure, large or carbohydratedense meals, alcohol, dehydration, and medications with potential for vasodilation, volume depletion, bradycardia, or sympatholytic medications (eg, antihypertensives, tricyclic antidepressants, diuretics, dopaminergic anti-parkinsonian agents, and phosphodiesterase inhibitors) could exacerbate OH symptoms.
Beta-blocker therapy has sympatholytic properties and is associated with a reduction in the patient's heart rate without significantly dropping the mean arterial pressure.
[alpha]2 adrenergic receptor agonists due to their sedative, analgesic, perioperative sympatholytic and hemodynamic stabilizing properties may be useful as adjuvants to intrathecal local anesthetics.
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