te·nof·o·vir

(tə-nŏf′ə-vîr)

An antiviral drug, C₉H₁₄N₅O₄P, used in the form of a prodrug (tenofovir disoproxil fumarate) to treat chronic hepatitis B and, in combination with other drugs, to treat HIV infection or to reduce the risk of HIV infection.

[teno-, of unknown origin + fo- (alteration of pho(spho)-) + (anti)vir(al).]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Translations

tenofovir

n tenofovir m

Mentioned in

Truvada

References in periodicals archive

Patients in four cohorts will be administered CRV431 in doses ranging from 75 mg to 375 mg in combination with 300 mg tenofovir disoproxil fumarate antiviral therapy, over a 28-day period.

Hepion Pharmaceuticals doses first HBV patient in CRV431 study

In a sub-analysis of the DISCOVER trial, Descovy reached intracellular drug concentration levels above the estimated protective threshold significantly more quickly than Truvada (emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg tablets; F/TDF), and additional pharmacokinetic data confirm that these drug concentration levels persist longer than Truvada.

Gilead Presents New Findings on Profile of Descovy for Potential Use as HIV Pre-exposure Prophylaxis Compared with Truvada

The victim compensation fund is being arranged for patients harmed after taking the company's TDF (tenofovir disoproxil fumarate) drugs as part of their treatment for HIV or AIDS or taken by uninfected individuals as part of the HIV prevention strategy called pre-exposure prophylaxis.

AIDS Healthcare Foundation calls on Gilead Sciences for USD10bn victim compensation fund

Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir diphosphate, a structural analog of deoxyadenosine triphosphate, which is the natural substrate for the viral enzyme reverse transcriptase.

Prevalence of Nephrotoxicity in HIV Patients Treated with Tenofovir Disoproxil Fumarate: A Single-center Observational Study

According to the company, Vemlidy is a novel, targeted prodrug of tenofovir that has demonstrated antiviral efficacy similar to Viread (tenofovir disoproxil fumarate, TDF) 300 mg, with better alanine aminotransferase normalisation and improved bone and renal safety at one-tenth of the dose.

Gilead Sciences Inc unveils Vemlidy in 25 mg for the once-daily treatment of adults with chronic hepatitis B

Tenofovir disoproxil fumarate is not recommended for those with creatinine clearance of less than 60 mL/min/1.73 [m.sup.2].

A look at new guidelines for HIV treatment and prevention

Tenofovir disoproxil fumarate monotherapy for nucleos(t)ide-naive chronic hepatitis B patients in Korea: data from the clinical practice setting in a single-center cohort.

A Rare Side Effect That May Be Due to Tenofovir Disoproxil Fumarate: Nail Pitting/ Tenofovir Disoproksil Fumarata Bagli Olabilecek Nadir Bir Yan Etki: Yuksuk Tirnak

Yuen, Chief of Gastroenterology and Hepatology, University of Hong Kong, and Principal Investigator for the ACHIEVE trial, will show the full 24-week clinical and virological data from the 25mg, 50mg and 100mg cohorts of inarigivir monotherapy, including sequential dosing data following the switch from inarigivir to tenofovir disoproxil fumarate (Viread(r)).

Principal investigators to present additional inarigivir results

"Long-acting injectable agents have the potential to prevent HIV acquisition without relying on adherence to a daily oral regimen," it notes.Currently, the only licensed pre-exposure drug is a daily oral pill called tenofovir disoproxil fumarate 300 mg plus emtricitabine 200 mg (TDF/FTC), and sold under the brand name Truvada.

Kenya to conduct trial on new HIV prevention drug