In this post-hoc analysis of 874 patients, treatment effect on serial brain volume, including thalamic volume and cortical grey matter, was evaluated by patient age at baseline, 12 months and 24 months.
Even for those who want to argue that the pain signal must be processed by the cortex to qualify, there is now evidence that the thalamic and subcortical structures are sufficiently mature, and have the necessary thalamocortical connections, in the words of Harvard anesthesiologist Roland Brusseau, that by the 20th gestational week, "it would appear possible that fetuses could experience something approximating 'pain'" (Brusseau and Myers, Journal of Emergency Nursing, 2006).
The researchers found that participants with MS presented with lower thalamic susceptibility (−7.5 versus −1.1 ppb) and higher susceptibility of basal ganglia (62 versus 54.8 ppb), compared with control participants.
Pathologically, FFI is characterized by severe and selective thalamic degeneration, especially in the mediodorsal and anterior ventral nuclei,[1],[17] in which more than 50% of the magnocellular and parvocellular neurons are lost as observed during autopsy.
[5] Surgical treatment such as thalamotomy or thalamic DBS for ET is reserved for selected patients with severe tremor who are unable to adequately respond to medical and physical therapy.
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