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Pharmaceuticals company Roche (SIX:RO)(OTCQX:RHHBY) stated on Tuesday that it has passed the US FDA clearance for the cobas Factor II and Factor V Test for use on the cobas 4800 system for testing of patients for inherited thrombophilia.

Roche wins US FDA clearance for Factor II and Factor V test on the cobas 4800 system for the diagnosis of suspected thrombophilia

M2 PHARMA-February 14, 2018-Roche wins US FDA clearance for Factor II and Factor V test on the cobas 4800 system for the diagnosis of suspected thrombophilia

Roche wins US FDA clearance for Factor II and Factor V test on the cobas 4800 system for the diagnosis of suspected thrombophilia

The SPS was first described in the 80s as a thrombophilia in which qualitative alterations of the platelet function increase its aggregation capacity, favoring in this way thrombosis with described cases of cerebrovascular disease, acute myocardial infarction, and ischemic retinopathy [7].

Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss

There are few reports describing the classical angiographic appearance of moyamoya vessels with abnormal thrombophilia profile.

Hyperhomocysteinemia in a Patient with Moyamoya Disease

Thrombophilia profiles showed a severe protein S deficiency (activity 13%) at birth which resolved at two months of age (activity 66%).

Umbilical Artery Thrombosis with Associated Acute and Severe Fetal Growth Restriction and Transient Severe Protein S Deficiency: Report of a Case with Prenatal Ultrasound Diagnosis Allowing for Timely Intervention and Good Outcome

HHT and thrombophilia are rarely seen concomitantly as two genetic disorders that exhibit theoretically opposite actions on hemostasis (2,3,4).

Cerebrovascular Events Secondary to Pulmonary Arteriovenous Malformation Based on Genetic Heterogeneity

In younger patients, inherited thrombophilia screening should also be considered, especially if VTE occurs recurrently or without obvious acquired reason (9).

EXTENSIVE DEEP VENOUS THROMBOSIS IN A YOUNG MALE PATIENT AS THE FIRST MANIFESTATION OF A RARE VENOUS ANOMALY--INFERIOR VENA CAVA DUPLICATION: CASE REPORT

The other diseases covered by the tests are celiac disease, alpha-1 antitrypsin deficiency, early onset primary dystonia, Factor XI deficiency, Gaucher disease type 1, glucose-6-Phosphate Dehydrogenase deficiency (also known as G6PD), hereditary hemochromatosis, and hereditary thrombophilia.

FDA approves first DTC genetic tests for disease risks

Both inherited and acquired thrombophilia factors are frequently identified in cases of large vein thrombosis [7].

Inferior Vena Cava and Renal Vein Thrombosis Associated with Thymic Carcinoma

Evidence of multiple arterial and venous clots in addition to the large cardiac thrombus raised the suspicion for inherited thrombophilia. The coagulability workup was performed and came back positive for protein C and S deficiency, with activity of 26% (normal range: 84-171) and 18% (normal range: 54-132% for females) for proteins C and S, respectively.

Large Left Ventricular Thrombus in a Patient with Systemic and Venous Thromboembolism Secondary to Protein C and S Deficiency

Here, we report a case of a paradoxical embolism caused by ASD involving only one kidney in the setting of an inherited thrombophilia.

Acute Unilateral Renal Infarction in the Setting of an Inherited Thrombophilia and Atrial Septal Defect