This
toxicant gained notoriety as a defoliant used by U.S.
The NIH also expects to invest in and develop four new environmental monitoring tests and devices each year to measure
toxicant exposures, dietary intake, and physical activity, and to determine individuals' biological responses to those influences.
While polyurethane floor finishes don't emit the
toxicant, he found, the more durable acid-cured resin finishes do.
Second, a team of physician scientists, research scientists trained in the basic biomedical disciplines, and public health researchers will work collaboratively to use
toxicant exposures or environmental perturbations to understand human disease.
Until recently, TCDD was considered the most potent dioxinlike
toxicant.
And there were hundreds of reported oil and
toxicant spills--including gas that may have seeped from an estimated 350,000 swamped cars--as well as drowned industrial and toxic waste dumps.
Little's worst-case analyses indicate that people showering for 10 minutes in water containing this VOC would inhale 50 percent more of the potential
toxicant than they would ingest by drinking two liters of that water.
Fourth are interdisciplinary approaches to the development of intervention and prevention strategies to alter the progression of environmentally induced human disease: 1) identification of novel compounds or engineering of biocompatible materials that protect against, inhibit, or reverse
toxicant actions and their validation in disease relevant settings; 2) development of mechanistically derived prevention strategies and application of them in populations with known genetic susceptibility to environmental stressors.
It now appears that the developing male reproductive system is more sensitive to the effects of this hormone-like
toxicant than any other organ or organ system studied, the Wisconsin scientists write.
Brian A Primack, M.D., Ph.D., from the University of Pittsburgh, and colleagues compared
toxicant load from waterpipe tobacco smoking and cigarette tobacco smoking among 3,254 young adults.
Specifically PD patients have greater percentage of B, C, and D categories (PD: none = 45.67%,
toxicant exposure 34.67%, positive family history 10.33%, and "double hit" 9.33%; controls: none = 64.3%,
toxicant exposure 29.7%, positive family history 3%, and "double hit" 3%; p < 0.00001).
In mice fed a high-fat diet, the team found no connection between PCB-77 exposure and effects like those seen in the low-fat group, despite the animals' having double the concentration of the
toxicant in fat tissue.