Bingham, director of the rheumatology clinics at John Hopkins University in Baltimore, reported that relative to patients treated with methotrexate only, patients who were given rituximab plus methotrexate mount a comparable recall response to tetanus
toxoid, a measure of retained immunity.
ACIP also clarified the poliovirus vaccination schedule that should be used with the combination vaccine DTaP-IPV/Hib (Pentacel), which contains diphtheria and tetanus
toxoids and acellular pertussis adsorbed, IPV, and Haemophilus influenzae type b conjugate (tetanus
toxoid conjugate).
Adult protection may be better than indicated by serosurveys and may have improved in the United Kingdom with use since 1994 of combined tetanus-diphtheria
toxoid vaccine instead of tetanus
toxoid for injuries (5).
The tetanus
toxoid, reduced diphtheria
toxoid, and acellular pertussis vaccine, adsorbed (Tdap) was licensed in June for use as a single-dose booster immunization in persons aged 11-64 and was previously recommended by ACIP for use in adolescents.
However, tetanus
toxoid is one of our safest and most effective immunizing agents.
Tetanus
toxoid, reduced diphtheria
toxoid, and acellular pertussis (Tdap) vaccine is recommended during the third trimester of each pregnancy to provide protection to newborns, who are at risk for pertussis-related morbidity and mortality (1).
Sanofi Pasteur, the vaccines division of the healthcare company Sanofi Group (Euronext:SAN) (NYSE: SNY), announced on Monday the approval by Health Canada of the expansion of the indication for Menactra (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria
Toxoid Conjugate Vaccine) down to infants nine months of age.
A new tool is now available to assist in controlling pertussis: the tetanus
toxoid, reduced diphtheria
toxoid, and acellular pertussis vaccine (Tdap).
In June 2005, a vaccine containing acellular pertussis antigens, tetanus
toxoid, and reduced diphtheria
toxoid (Tdap) was licensed for use in persons aged 11-64 years.
Safety, reactogenicity, and immunogenicity of a tetravalent meningococcal polysaccharide-diphtheria
toxoid conjugate vaccine given to healthy adults.
Those of us who were immunized in infancy received a triple vaccine, DPT, containing diphtheria, pertussis (whooping cough), and tetanus
toxoid. If first immunized in military service, we were given Td, a dual vaccine that omits the pertussis
toxoid and contains a smaller amount of diphtheria
toxoid, which can cause adverse reactions in adults.
The technique uses a part of the Haemophilus bacterium that would normally stimulate only a weak immune response (a "hapten') and links it to a potent immune system stimulant, or "carrier' --in this case a protein component of diphtheria
toxoid. The resulting antibody response is rich in Haemophilus-specific "memory cells' that enable infants to mount an amplified attack against the bacteria.