Whether to regulate stem cells by affecting their reprogramming, self-renewal, or differentiation, or to better understand mechanism of cancers by targeting
tumorigenic signaling nodes, finding the right small molecule is of vital importance to the success of a research project.
Accordingly, elevated NF[kappa]B signaling in IECs enhances WNT signaling and causes a
tumorigenic cell reprogramming process, which leads to the onset of SC-like cells with tumor initiation capacity.
During the
tumorigenic process the signaling is deregulated, thus allowing the mammary epithelium to expand, proliferate, and invade neighboring tissue (hyperplasia) (MIHEVC & DOVC, 2013).
The results show that the
tumorigenic potential of the cGMP manufactured ISC-hpNSC is negligible with no detectable undifferentiated pluripotent stem cells, providing additional assurance to their clinical translation, the company said.
Does Vanicream contain a
tumorigenic ingredient comparable to mineral oil?
(1,2) Overall changes in cell surface glycoconjugates are also evident in studies on the differences in lectin binding and lectin-induced agglutination of cancer cells with a focus on the facts showing that lectin-resistant cancer cells acquire reduced
tumorigenic and/or metastatic potentials as compared with the parental malignant cells.
Moreover, clinical applications require subsequent redifferentiation into a specific cell type, and undifferentiated iPSCs maybecome
tumorigenic by incomplete differentiation of iPSCs.
MNU-MECs (WPE1-NB26 cells), derived from second generation tumors formed in nude mice by MNU-transformed RWPE-1 cells (10 [micro]g/mL MNU for 1 hr for four cycles), are
tumorigenic in vivo (Webber et al.
Metabolic alterations in highly
tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis.
This prevents telomeres from shortening and extends the life of these
tumorigenic cells -- a significant contributor to cancer progression.
A further level of complexity to the understanding of cancer biology comes from the knowledge that the neoplastic cell populations within tumors comprise heterogeneous cell populations, in which cells having different
tumorigenic potential coinhabit single tumors.