Phase I and pharmacokinecti study of the new
vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advenced solid tumors.
(3) Additionally, the use of a
vinca alkaloid in conjunction with a steroid is associated with better outcomes than either of these agents alone.
Vincristine is a
vinca alkaloid used in combination with other agents, usually in the treatment of pediatric malignancies, including acute lymphoblastic leukemia (ALL).
In 1976, Potier's team discovered that the Tubulin test proved a semi-synthesis of one
vinca alkaloid compound to be active, showing promise as an anticancer drug.
Conophylline (27): Conophylline (27) is a
vinca alkaloid from T.
Patients who fail to improve on this regimen should be given a course of either a
vinca alkaloid or etoposide.
Vintafolide is an investigational, injectable SMDC featuring folate (vitamin B9) linked to a potent
vinca alkaloid cytotoxic agent, desacetylvinblastine hydrazide (DAVLBH).
Vintafolide is an investigational, proprietary, injectable SMDC consisting of folate (vitamin B9) linked to a potent
vinca alkaloid cytotoxic agent, desacetylvinblastine hydrazide (DAVLBH).
Vintafolide is an investigational proprietary, injectable, SMDC consisting of folate (vitamin B9) linked to a potent
vinca alkaloid chemotherapy agent, desacetylvinblastine hydrazide (DAVLBH).
Vintafolide is a conjugate of the vitamin folate and a super-potent
vinca alkaloid. Etarfolatide is a folate-targeted molecular imaging agent that is being developed as a non-invasive method to identify tumours that over-express folate receptors.