"We know that annual administration of intravenous
zoledronate (also known as zoldedronic acid) at the 5-mg dose is an effective treatment for preventing fractures and decreasing fractures in osteoporotic, postmenopausal women by 25%-70%, depending on the skeletal site.
BOSTON -- An annual dose of
zoledronate that has been reduced by 50% or even 80% appears to be as effective as the recommended 5-rag dose in increasing bone mineral density and decreasing markers of bone turnover in osteopenic postmenopausal women, according to Dr.
FDA-Approved Drugs for the Treatment and/or Prevention of Postmenopausal Osteoporosis Indications Drug Class Drug Name Prevention Treatment Bisphosphonates Alendronate X X Risedronate X X Ibandronate, oral X X Ibandronate, IV X
Zoledronate X X Hormonal Systemic estrogen X Salmon calcitonin X Teriparatide X Selective estrogen Raloxifene X X receptor modulator (SERM) Biologics Denosumab X FDA=US Food and Drug Administration,; IV=intravenous.
Slender white men seem to be at greatest risk, she said, noting that both pamidronate and
zoledronate have been shown to prevent bone loss caused by androgen deprivation therapy.
Mean cumulative doses of the bisphosphonates used (pamidronate and
zoledronate) were significantly higher, and duration of disease and follow-up were significantly longer, in ONJ patients than in those who didn't develop ONJ.
A series of papers since 2003 have reported this complication with alendronate, pamidronate and
zoledronate therapy.
At each time point, the reduction in cathepsin K was significantly greater among the 20 patients treated with
zoledronate than in the 40 who received pamidronate.
Bisphosphonates, such as pamidronate and
zoledronate, are easily administered through intravenous (IV) infusions and are aimed at preventing or slowing bone destruction and reducing pain and risk of fracture, therefore prolonging the dog's life.
Treatment with
zoledronate 6 months after the last denosumab injection achieves partial preservation of BMD, but multiple vertebral fractures have still been reported when raloxifene, ibandronate, or alendronate have been given after stopping denosumab, she said.
Osteopenia treatment includes medications, which include bisphosphonate medications, such as ibandronate (Boniva), alendronate (Fosamax), risedronate (Actonel),
zoledronate (Reclast) and raloxifene (Evista).
Investigators in New Zealand recently published the results of a randomized controlled trial they conducted to determine the efficacy of
zoledronate (zoledronic acid) in preventing fractures in postmenopausal women.
12, 2018 (HealthDay News) -- The risk for fragility fractures is significantly lower in women with osteopenia who receive
zoledronate than in those who receive placebo, according to a study published online Oct.