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abasic |
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SSB Endo III
sites, reflecting abasic sites and oxopyrimidines, were evaluated by a
modified version of comet assay with Endo III treatment (Collins et al. Apurinic/apyrimidinic (AP)
endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and
initiates repair of this cytotoxic/mutagenic lesion by incising the DNA
backbone via a [Mg. The major human abasic endonuclease:
formation, consequences and repair of abasic lesions in DNA. |
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