The mucous-producing neoplastic cells formed acinar
structures containing swollen cells with abundant clear cytoplasm and round central nuclei, or nuclei displaced to the periphery (signet-ring cells).
Secretory granules first appeared in the cell apex of the luminal acinar
cells at this stage of prenatal life (Fig.
The diagnosis of solid pseudopapillary tumors on trucut biopsies and excision biopsies poses a great difficulty for the pathologist, as due to their similarity with other endocrine and exocrine pancreatic tumors including pancreatic neuroendocrine tumor, Pancreatoblastoma and acinar
108) Otherwise, only rare cases of pancreatic acinar
cell carcinoma (including mixed acinar
ductal carcinoma and mixed acinar
neuroendocrine carcinoma) have been found to show albumin positivity.
The pathophysiology of acute pancreatitis is not obvious, although intracellular activation of the digestive enzymes in acinar
cells is accepted as the starting point.
38) Finally, it should be noted that parenchymal cells such as hepatocytes (39) and pancreatic acinar
cells express functional NOD1; (12-14) in the latter case, sensing of commensal organism-derived PGN by NOD1 mediates acute and chronic pancreatitis as discussed in greater detail below.
Histologically, the NHs were composed of the proliferation of mucussecreting acini with preservation of the normal duct to acinar
The goal of the Moffitt clinical trial was to evaluate if a one-year intervention with green tea catechins could suppress prostate cancer development in men who had high-grade intraepithelial neoplasia or atypical small acinar
CM4620 inhibits the uncontrolled increase in intracellular calcium in pancreatic acinar
cells, preventing inappropriate digestive enzyme activation, acinar
cell dysfunction and death, or necrosis.
In some cases of mimickers of carcinoma, a diagnosis of suspicious of atypical small acinar
proliferation, but not diagnostic of malignancy has to be given.
75%) followed by acinar
adenocarcinoma (28 cases--25%).
CLDN2 is an X-linked gene involved in tight junction permeability and is expressed by pancreatic acinar