active placebo


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Noun1.active placebo - a placebo used in experimental tests of a drug that has noticeable side effectsactive placebo - a placebo used in experimental tests of a drug that has noticeable side effects; "an active placebo mimics the side effects of the experimental drug"
placebo - an innocuous or inert medication; given as a pacifier or to the control group in experiments on the efficacy of a drug
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So with a lower dose of MDMA in the active placebo, it might fool the subject or the therapist.
To account for that possibility, he said some researchers are using more active placebos such as midazolam, but he did not think that it was a complete solution because the ideal active placebo would affect glutamate, dopamine, and noradrenaline without having an antidepressant effect.
Limitations of the study included the use of an active placebo (although with no noted CNS effects), the allocation of all moderate-severely anxious individuals into one group and a short wash-out period with potential carryover effect of the herb.