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acute lymphocytic leukemia |
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| People with acute lymphocytic leukemia are more likely than healthy
people to have the common version of a gene that plays a role in
regulating folic acid metabolism in the body, a new study shows. The study is a multi-center, open label, dose escalation trial and
will investigate the safety, tolerability, pharmacokinetics and
preliminary efficacy of INNO-406 in adult patients with
imatinib-resistant or intolerant Philadelphia positive (Ph+) leukemias
or relapsed/refractory Ph+ acute lymphocytic leukemia (ALL). Of the 20 with lymphoid blast crisis or acute lymphocytic leukemia,
70 percent had a response, including four with complete responses, the
researchers said. |
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acute lymphocytic leukemia - acute leukemia characterized by proliferation of immature lymphoblast-like cells in bone marrow, lymph nodes, spleen, and blood; most common in children