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2, ATC code: J05AF08, Generic Name: Adefovir dipivoxil, Pharmaceutical form: Tablets Strength: 10 mg, Unit Value: 10 mg, Quantity in units 4 185 thereof.
Overall, 42% of the patients had received lamivudine (Epivir), 32% had received adefovir (Hepsera), 10% had received tenofovir (Viread), 9% had received telbivudine (Tyzeka), and 7% had received entecavir (Baraclude).
This step is mainly targeted by nucleos(t)ide analogues such as lamivudine, adefovir, entecavir, tenofovir, and telbivudine.
Bristol-Myers said Baraclude showed greater viral suppression in patients when compared with adefovir in a late-stage study.
True (A) or false (B)--click on the correct answer: Other agents active against hepatitis B mono-infection include entecavir, adefovir and telbivudine.
Pegylated interferon-alpha (pegIFN-[alpha]) may be considered in HBeAg+ carriers, while at this time adefovir seems to be the only option for HBeAg-negative patients.
Since 1996, four oral antiviral medications have been approved by the Food and Drug Administration for treatment of hepatitis B: lamivudine, adefovir dipivoxil, entecavir and telbivudine.
Adefovir dipivoxil (Hepsera), a nucleotide analogue approved in 2002, is active against lamivudine-resistant virus, but can cause nephrotoxicity.
Three drugs have been approved for chronic HBV treatment, alpha-interferon, lamivudine, and adefovir.
Participants will be given adefovir (brand name: Hepsera) or Viread to treat the hepatitis B.
Human safety data were very good -- in particular, there was none of the kidney toxicity that had been seen in adefovir when studied for HIV at doses of 60 and 120 mg daily.
But Federal agencies like the Food and Drug Administration (FDA) have also had their swings, from the approval of nelfinavir without a public meeting to the rejection of adefovir dipivoxil much to the disappointment of many, especially its developer.
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