adenylate cyclase

(redirected from adenylate)
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Related to adenylate: adenylate cyclase, adenylic acid

a·den·yl·ate cyclase

(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also a·den·yl cyclase (ə-dĕn′əl, ăd′n-ĭl)
An enzyme that catalyzes the formation of cyclic AMP from ATP and plays a key role in signal transduction.

References in periodicals archive ?
This new study used genome sequencing and found mutations in one specific gene related to obesity: adenylate cyclase 3 (ADCY3).
The sedative effect of dexmedetomidine is probably mediated by the activation of presynaptic a-2 adrenoreceptors in the locus coeruleus, leading to inhibition of release of norepinephrine, along with it, inhibition of adenylate cyclase may lead to hypnotic response.
Salbutamol elevates intracellular concentration of cyclic AMP (cAMP) by activating adenylate cyclase.
i] class tend to be inhibitory guanosine triphosphate (GTP)-binding regulators of adenylate cyclase ("i" indicates inhibitory), while members of the [G[alpha].
The viability of the cell of organ and tissue is maintained when the adenylate energy charge of the cell is equal to the value of one (Atkinson, 1968) (Figure 1).
6] It is also involved in several processes including hormone receptor binding; gating of calcium channels; transmembrane ion flux and regulation of adenylate cyclase; muscle contraction; neuronal activity; control of vasomotor tone; cardiac excitability; and neurotransmitter release.
Cloning, tissue distribution and effects of food deprivation on pituitary adenylate cyclase activating polypeptide (PACAP) / PACAP-related peptide(PRP) and preprosomatostatin 1 (PPSS 1) in Atlantic cod (Gadus morhua).
MC1R is activated by alpha-melanin stimulating hormone in melanocytes, and then stimulates the G[alpha]s to produce cAMP in melanocytes by the function of adenylate cyclase, resulting in eumelanin production (Robbins et al.
7) Resistance to aminoglycosides is related to the overexpression of efflux pumps or production of modified enzymes of phosphorylate, acetylate, or adenylate.
To investigate the mechanism underlying the endotheliumi-ndependent relaxation, inhibitors of cyclic adenylate cyclase (SQ 22536, 10 [micro]M) and soluble guanylate cyclase (ODQ 10 [micro]M) were used.