Auditory brainstem response wave I was mainly sourced from the cochlear afferent nerve
,9 and the auditory brainstem response missed from wave I, suggesting that the lesions of auditory branch and/or inner hair cells, inner hair cells and afferent synapses of VIII brain nerve leads to unsynchronized nervous discharge of the nerve fibers.
Externally administered AEA and CB1 agonist, arachidonyl-2-chloroethylamide (ACEA), have been shown to significantly reduce the firing rate of afferent nerve
fibers in OA joints, but not in the control joints, suggesting a tonic release of endocannabinoids at the joint level in OA.
The US Food and Drug Administration (FDA) has approved Sorrento Therapeutics's Investigational New Drug Application (IND) for Resiniferatoxin (RTX), a non-opioid, TRPV1 agonist that selectively targets afferent nerve
activation involved in chronic pain states.
The analgesic effects of direct current are explained by effects of iones on C afferent nerve
fibers, as well as by application of different ionic content, while neuromodulatory effect is explained by release of neuropeptide transmitters [3, 9].
Tissue injury stimulates C and Ad-fibers of sensory nerves, which causes the release of the inflammatory neuropeptides substance P and Calcitonin-generelated-peptide from the afferent nerve
Urethral afferent nerve
activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability.
The etiology of NP remains unknown, although it is thought to be a neuropathic itch caused by afferent nerve
Amino glycosides including streptomycin have been found to cause modulation of the release of excitatory neurotransmitters from primary afferent nerve
proposed a model of AD in which increased NGF in the injured cord stimulates primary afferent nerve
sprouting, thus amplifying spinal sympathetic reflexes and promoting dysreflexia .
This pathologic change prompts the surviving primary afferent nerve
fibers, after being damaged, and to form new connections - the regeneration of the central synapse with the bone pain signal transmitting neurons.
The characterization of afferent nerve
fiber function using quantitative sensory testing and histamine-induced flare analysis showed that PHN is associated with damage of afferent fibers.