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agranulocytosis

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.03 sec.
a·gran·u·lo·cy·to·sis  (-grny-l-s-tss)
n.
An acute disease marked by high fever and a sharp drop in circulating granular white blood cells. It may be drug-induced or the result of exposure to radiation.
agranulocytosis [əˌgrænjʊləʊsaɪˈtəʊsɪs]
n
(Medicine / Pathology) a serious and sometimes fatal illness characterized by a marked reduction of leucocytes, usually caused by hypersensitivity to certain drugs
[New Latin; see a-1, granule, -cyte, -osis]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.agranulocytosis - an acute blood disorder (often caused by radiation or drug therapy) characterized by severe reduction in granulocytes
agranulosis, granulocytopenia
blood disease, blood disorder - a disease or disorder of the blood


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78650 Chest pain unsp V717 Observe susp Cardiovas dis 78659 Chest pain oth sp 78651 Precordial pain LOOK FOR: anemia, pancytopenia, aplastic anemia, dehydration, malnutrition, Agranulocytosis, thrombocytopenia, bleeding, obstruction, resp comp, aspiration, complex pneumonia, (gram-neg.
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For example, clozapine can cause sedation or anticholinergic effects, as well as increased agranulocytosis and delirium in older patients.
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The first of these, clozapine (Clozaril[R]), has been shown to be more effective than other antipsychotics, although the possibility of severe side effects -- in particular, a condition called agranulocytosis (loss of the white blood cells that fight infection) -- requires that patients be monitored with blood tests every one or two weeks.
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