In trials, adverse reactions reported in at least 5% of treated patients and occurred at least twice more often than those on placebo: akathisia
, oral hypoes-thesia, and somnolence in patients with schizophrenia, and somnolence, dizziness, extrapyramidal symptoms, other than akathisia
, and weight increases among bipolar patients, according to the prescribing information.
There was a modest but significant worsening at endpoint in akathisia
symptoms (assessed using the Barnes Akathisia
Scale) for lurasidone versus placebo.
The most commonly observed adverse reactions (≥5% and at least twice that for placebo) in patients treated with lurasidone in short-term clinical studies were somnolence, akathisia
, nausea and parkinsonism.
5 -- 6 mg/day vs placebo) were: extrapyramidal symptoms (15%, 19% vs 8%) and akathisia
(9%, 13% vs 4%)
, headache, and anxiety were the most common adverse side effects.
The most common side effect of the new drug is the feeling the need to move constantly, medically called akathisia
The most frequent adverse reactions seen in short-term clinical studies (incidence[greater than or equal to] 5% and at least twice as frequent as with placebo) were somnolence, akathisia
, nausea, parkinsonism and dystonia.
Adult patients with bipolar depression: akathisia
, extrapyramidal symptoms, and somnolence
Extrapyramidal symptoms were evaluated using the Simpson-Angus scale (Simpson and Angus 1979), Barnes Akathisia
scale (Barnes 1989), and abnormal involuntary movement scale (AIMS) (National Institute of Mental Health 1976b).
Moreover, there is evidence that abnormalities of 5-HT functions are related to the pathophysiology of diverse neurological conditions including Parkinson's disease, tardive dyskinesia, akathisia
, dystonia, Huntington's disease, familial tremor, restless legs syndrome, myoclonus, Gilles de la Tourette's syndrome, multiple sclerosis, sleep disorders, and dementia.
is a rare clinical condition that can occur after traumatic brain injury (TBI).
Participants were also assessed utilizing the Barnes Akathisia
Ratings Scale (BARS) for akathisia
and the Simpson-Angus Scale (SAS) for parkinsonism.