Previous investigations on this plant resulted in isolation of irregular triterpenes, perdione and perovskone, and a large amount of tanshinones with their reported biological activities including effects on cardiac function [14-16], aldose
reductase inhibition , anti-oxidant [18,19], cytotoxic , binding activities with the benzodiazepine receptor , and apoptosis induction .
Salacia has also been found to inhibit aldose
reductase, an enzyme normally present in the eye and in other parts of the body that facilitates the transformation of glucose into a sugar alcohol called sorbitol.
Hinton CL, Macara T The determination of aldose
sugars by means Of chloramine-T, with special reference to the analysis of milk products.
Higher body mass index (BMI) is associated with DR because of potential involvement of blood viscosity, altered platelet function, aldose
reductase activity and vasoproliferative parameters e.
The major metabolic changes occurring at the cellular level are: increased aldose
reductase activity (polyol-sorbitol pathway], diacylglycerol--protein kinase C activation  (myo-inositol pathway], the hexosamine activation pathway and formation of advanced glycation end products (AGEs].
One of the pathogenesis mechanism is aldose
reductase initiated accumulation of sorbitol leading to selective degeneration of mural cells in the retinal capillaries.
Structures and aldose
reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.
dorsalis MAG/ED transcriptome, aldose
reductase unigenes, 6-phosphofructo kinase, fructose-1, 6-bisphosphatase, and fructose 1,6 bisphosphate-aldolase were identified (Wei et al.
1: Reactions in the model containing AKR7A2 in the Gene-Protein-Reaction rules Reaction IDs are those from Recon 2 Reaction ID Reaction name ALR2 Aldose
reductase (methylglyosal) ALR3 Aldose
reductase (acetol) SBTR D-sorbitol reductase ARABR Arabinose reductase LALDO2x D-Lactaldehyde:NAD+ 1-oxidoreductase PPDOx Propane-1,2-diol:NAD+ 1-oxidoreductase Reaction ID GPR rule GPR rule (gene ID) ALR2 (8574.
Identification of phenolic compounds isolated from pigmented rices and their aldose
reductase inhibitory activities.
Inhibition of aldose
reductase by Aegle marmelos and its protective role in diabetic cataract.
reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.