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alkylating agent

   Also found in: Medical, Legal, Financial, Encyclopedia, Wikipedia, Hutchinson 0.04 sec.
alkylating agent [ˈælkɪˌleɪtɪŋ]
n
(Medicine / Pharmacology) any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapy
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.alkylating agent - an antineoplastic drug used to treat some forms of cancer
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
chlorambucil, Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer


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TEMODAL (temozolomide) Capsule is an oral, cytotoxic alkylating agent indicated for treating glioblastoma multiforme (GBM).
The compounds tested thus far include N-methyl-N'-nitro-nitrosoguanidine (an alkylating agent similar to methyl methane sulfonate) and cadmium (a toxic metal found in tap water).
Using these and other factors, the retrospective study of more than 9,000 patients provides strong statistical evidence that approximately half of the secondary bone cancers observed can be blamed on radiation therapy or on chemotherapeutic alkylating agents such as the frequently prescribed cyclophosphamide.
 
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