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alkylating agent

   Also found in: Medical, Legal, Financial, Encyclopedia, Wikipedia 0.01 sec.
alkylating agent [ˈælkɪˌleɪtɪŋ]
n
(Medicine / Pharmacology) any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapy
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.alkylating agent - an antineoplastic drug used to treat some forms of cancer
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
chlorambucil, Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer
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Cisplatin was the first drug to be discovered in the class of alkylating agents {it was discovered about 30 years ago}and it has more side effects than the newer generations of alkylating agents, so most doctors would have tried to use one of the newer chemotherapy agents before recommending treatment with Cisplatin.
Mesothelioma Chemotherapy-What Is the Role of Cisplatin? by Bello Kamorudeen / Health, general community
The drug is currently not approved for the treatment of multiple sclerosis but is indicated for treating B-cell chronic lymphocytic leukemia in patients who have been treated with alkylating agents and who have failed fludarabine therapy.
MS drug linked to one death in clinical trial by Wachter, Kerri / Clinical Psychiatry News
The final section of the text is dedicated to molecular principles applied to specific toxicants and includes chapters on alkylating agents and "mustards," oxidative stress in the erythrocyte, aromatic amines and related toxic compounds, polycyclic aromatic hydrocarbon carcinogens, and acetaminophen.
Molecular Toxicology, 2d ed by SciTech Book News
 
 
 
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