Immune neutropenia may result from granulocyte-specific autoantibodies, granulocyte-specific alloantibodies
, or transfusion-related anti-HLA antibodies.
The latter safety measure should be designed into manual and computerized record-keeping systems to warn of any previous ABO/Rh typing discrepancies, known alloantibodies
, previous transfusion reactions, special component requirements, and the availability of reserved autologous or designated units.
would immediately recognize a transplanted kidney as "foreign" and mount an immune attack against it.
Cheng CK, Wong ML, Lee AW PEG adsorption of autoantibodies and detection of alloantibodies
in warm autoimmune hemolytic anemia.
For this study, lymphocytes were tested with a panel of sera containing well-characterized HLA-specific alloantibodies
All eight recipients became insulin independent, but three did not maintain independence, including two who tested positive for autoantibodies and alloantibodies
As patients undergo subsequent transfusions, alloantibodies
to multiple antigens may develop.
2: Delivery of cards (cassettes) and the reference cell alloantibodies
immunological assays and testing compliance without ABO and RhD signs of the donor and the recipient, including the lease of equipment.
This is particularly important when managing patients who receive chronic transfusions, including those with sickle cell disease, thalassemia, or chronic anemia, who are more likely to produce alloantibodies
Pathophysiologically, the binding of auto- or alloantibodies
to factor VIII impedes its clotting activity, with potentially life-threatening complications.
Solid-phase methods, such as enzyme-linked immunosorbent assays (ELISAs) and Luminex (Luminex, Austin, Texas) technology, are increasingly considered to be the methods of choice for characterizing HLA alloantibodies
CryoLife notes that the effect of reduced alloantibodies
on the long-term durability, or long-term resistance to rejection by the patient, of the CryoValve SG has not yet been clinically proven.