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allosteric

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
al·lo·ster·ic  (l-strk)
adj.
Of or involving a change in the shape and activity of an enzyme that results from molecular binding with a regulatory substance at a site other than the enzymatically active one.

allo·steri·cal·ly adv.
al·loster·y (-lst-r) n.

allosteric [ˌæləʊˈstɪərɪk]
adj
(Life Sciences & Allied Applications / Biochemistry) Biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule


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During the study, the researchers conducted trials with the help og potential drug candidate ADX10059, a negative mGluR5 allosteric modulator.
INTRODUCTION Allosteric regulation of enzyme activity is widely used by living cells to control diverse physiological processes [1,2].
Coverage includes an introduction to signaling molecules and their receptors; an overview of the technical approaches to investigating these interactions; structural, functional, and pharmacological aspects of GPCRs; the analysis and interpretation of experimental data; the use of recombinant cell lines, receptor mutants and related artifices in drug research; and several trendy but often poorly understood concepts such as insurmountable antagonism, inverse agonism, and allosteric interactions.
 
 
 
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