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allosteric
(redirected from allosteric site)

    Also found in: Medical, Legal, Financial, Encyclopedia, Wikipedia, Hutchinson 0.02 sec.
al·lo·ster·ic  (l-strk)
adj.
Of or involving a change in the shape and activity of an enzyme that results from molecular binding with a regulatory substance at a site other than the enzymatically active one.
allo·steri·cal·ly adv.
al·loster·y (-lst-r) n.
allosteric [ˌæləʊˈstɪərɪk]
adj
(Life Sciences & Allied Applications / Biochemistry) Biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule


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This model suggested that SULT1E1 could bind two molecules of estradiol per molecule of enzyme, one at a preferred site for sulfonation and the other at an allosteric site associated with substrate inhibition (Zhang et al.
In vitro inhibition of human hepatic and cDNA-expressed ... by James, Margaret O. / Environmental Health Perspectives
In its lead inflammation program, Locus has created exquisitely selective p38 inhibitors which bind to p38 at an allosteric site and do not involve the ATP site.
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Allosteric sites may offer an improved safety profile over ATP site inhibitors as well as provide a dual mode of action.
Locus Announces Continuing AIDS Collaboration with Weill Cornell ... by Business Wire
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