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allosteric
(redirected from allosterically)

    Also found in: Medical, Wikipedia 0.01 sec.
al·lo·ster·ic  (l-strk)
adj.
Of or involving a change in the shape and activity of an enzyme that results from molecular binding with a regulatory substance at a site other than the enzymatically active one.
allo·steri·cal·ly adv.
al·loster·y (-lst-r) n.
allosteric [ˌæləʊˈstɪərɪk]
adj
(Life Sciences & Allied Applications / Biochemistry) Biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule
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Recently it was shown that the binding effectiveness of ATP analogue [beta], [gamma]-imidoadenosine 5'-triphosphate (AMPPNP) and peptide substrate LRRASLG (kemptide) with protein kinase A is effectively controlled allosterically [13].
Single-subunit allostery in the kinetics of peptide phosphorylation ... by Kuznetsov, Aleksei; Jarv, Jaak / Proceedings of the Estonian Academy of Sciences
It is a reversible competitive AChE inhibitor that also allosterically modulates nicotinic receptors (this effect is probably independent of its cholinesterase inhibition).
Acetylcholinesterase inhibitors from plants by Mukherjee, Pulok K.; Kumar, Venkatesan; Mal, Mainak; Houghton, Peter J. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Ligand binding to the peripheral site can block access of substrates or allosterically alter the catalytic efficiency of AChE, but more importantly for our considerations, it interferes with its nonenzymatic adhesion functions that are required for axonogenesis and other developmental events (Bourne et al.
Nonenzymatic functions of acetylcholinesterase splice variants in the ... by Slotkin, Theodore A. / Environmental Health Perspectives
 
 
 
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