2013) Modulation of allostery
by protein intrinsic disorder.
com)-- Terry Hebert, Professor of Pharmacology and Therapeuticsat at McGill University, will give a presentation on, "Assessing Bias and Allostery
in GPCRs using Conformational Biosensors" at GTCbio's 4th GPCR in Drug Discovery Conference to be held on September 14-15, 2016 in Boston, MA.
Specific topics include from classical thermo-chemistry to monitoring living organisms, thermotropic properties of ceramides in aqueous or lipidic environments, allostery
and cooperative interactions in proteins assessed by isothermal titration calorimetry, protein stability in crowded environments, and calorimetry to monitoring mixed bacterial populations and biofilms.
in a monomeric protein: the case of human serum heme-albumin.
In summary we will develop a method that will make it possible to describe some of the most fascinating biological phenomena, such as allostery
and signal transduction, and will, in the long term, be an instrument for the discovery of drugs to treat castration resistant prostate cancer, a late stage of prostate cancer that is incurable and kills ca.
The greatest potential for impact is in drug discovery and understanding biophysical processes--fundamental questions like allostery
," he says, referring to the subtle process by which biological molecules go about binding to one another.