Non-viral delivery of self-amplifying mRNAs (SAM technology), derived from a modified alphavirus
single-stranded (ss) RNA genome, elicits very potent and broad-based immune responses due to antigen expression in host cells and to their intrinsic innate immune stimulating capabilities.
Utilizing these virus-like particles, VLP Therapeutics has developed a proprietary, "plug-and-play" platform called inserted alphavirus
virus-like particle (i-?
It is an RNA virus that belongs to the alphavirus
genus of the family Togaviridae.
Mayaro virus (MAYV; genus Alphavirus
, family Togaviridae) is an arbovirus transmitted primarily by the bite of female mosquitoes of the genus Hemagogus, usually from an infected non-human primate (monkeys) to a susceptible human.
Paradigm Biopharmaceuticals (ASX: PAR) has dosed the first participant in its Phase 2 Alphavirus
clinical trial assessing the drug pentosane polysulfate sodium (PPS) for the treatment of Ross River virus, Proactive Investors reported on Wednesday.
Chikungunya (CHIKV) is a reemerging arbovirus that belongs to the Alphavirus
genus of the Togaviridae family.
Most mosquitoes were tested with a RAMP* WNV test and the VecTOR Test Systems (Thousand Oaks, California) Alphavirus
panel that detects chikungunya (CHIK), equine encephalitis, Mayaro, SINV, Venezuelan equine encephalitis, and Western equine encephalitis viruses.
, chikungunya virus makes most affected individuals quite ill, and serum IgG and IgM titers persist long after infection Testing is straightforward, as long as the virus is a candidate diagnosis, Dr.
Chikungunya, an alphavirus
, appeared abruptly in developing countries of the Americas, revealing that we were not prepared to face it.
Among their topics are the accurate determination of the position and shape of heavy-atom replacement groups in proteins, processing oscillation diffraction data for very large unit cells with an automatic convolution technique and profile fitting, the three-dimensional structure of canine parvovirus and its functional implications, combining electron microscopic with X-ray crystallographic structures, and structural changes of envelope proteins during alphavirus
Solubilization and immunoprecipitation of alphavirus
Additionally, it is a vector of 22 arboviruses: Flavivirus (dengue, West Nile virus, yellow fever), Alphavirus
(chikungunya, Eastern Equine Encephalitis virus), Orthobunyavirus (Tensaw virus, Potosi virus, Cachey Valley virus, LaCrosse virus), and nematodes [Dirofilaria immitis (Leidy, 1856), Dirofilaria repens Railliet & Henry, 1911] (Cancrini et al.