alternative pathway


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Related to alternative pathway: classical pathway

alternative pathway

n. Immunology
The activation of complement by direct contact with polysaccharides located on the surface of bacteria or other pathogens. In contrast to the classical pathway, the alternative pathway is a nonspecific immune response that does not rely on the presence of antibodies.
References in periodicals archive ?
TXA302 is a proprietary analogue of the naturally occurring peptide angiotensin, which is part of an alternative pathway of the renin-angiotensin system.
According to the company, TXA302 is a proprietary analogue of the naturally occurring peptide Angiotensin (1-7), which is part of an alternative pathway of the renin-angiotensin system, used in the treatment of stroke.
9,796,741, entitled "Aryl, Heteroaryl, and Heterocyclic Compounds for Treatment of Complement Mediated Disorders," has been granted with claims to compositions of matter for ACH-4471 and additional compounds that inhibit complement factor D activity, a key mediator in the complement alternative pathway (AP).
State flagship Indiana University Bloomington does not accept the alternative pathway.
The Alternative Pathway group included dentists working in the public sector dental workforce scheme, or as academics/researchers/students or specialists or those who migrated to Australia at a time when mutual qualifications from other countries were recognised.
In contrast to the multiple origins of autophagic membranes of conventional autophagy, the membranes observed during activation of the alternative pathway appear to originate exclusively from the Golgi apparatus.
If alternative pathway programs become incentivized at a national level, we must be prepared to challenge their negative impact using research on teacher preparation, teacher quality, and student learning.
However, factor H, factor I, and MCP can mediate the conversion of C3b into the inactive form C3bi, to block the complement reaction activated by the alternative pathway and to prevent the body from being attacked by the complement system.
John Erickson, president of Consumer Banking and president, California, CIT Bank, said, 'The Innovative Impact Fund Youth Entrepreneur Academy provides a viable alternative pathway for underserved youth to use their talents, skills and passions to make a positive impact on their life and the lives of others.
Hussein describes the re-emergence of the single-state resistance movement in the context of the Oslo Accords as an alternative pathway toward a lasting, peaceful resolution of the conflict.
The alternative pathway of complement system activation [17] and oxidative stress [18] are also considered noteworthy participants in SLE pathogenesis.
Such an alternative pathway could open the door to the preparation of different cell types for cancer therapy.

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