amantadine


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a·man·ta·dine

 (ə-măn′tə-dēn′)
n.
A drug, C10H17, used in its hydrochloride form as an antiviral agent and treatment for Parkinson's disease.

[Alteration of adamantane, a hydrocarbon + -ine.]

amantadine

(əˈmæntəˌdiːn)
n
(Pharmacology) an antiviral drug used in the treatment of some types of influenza and to reduce some of the symptoms of Parkinson's disease
[C20: a blend of amine + adamantane the chemical compound from which it is derived]

a•man•ta•dine

(əˈmæn təˌdin)

n.
a water-soluble crystalline substance, C10H17NHCl, that inhibits penetration of viruses into cells and is used against certain types of influenza and in the treatment of parkinsonism.
[1960–65; coinage appar. based on the chemical name 1-aminoadamantane]
Translations

amantadine

n amantadina
References in periodicals archive ?
To evaluate its efficacy and tolerability, we performed a retrospective study of consecutive patients with Parkinson's disease (PD) who had received amantadine either as mono- or combination therapy for a 3-year period.
Evidence of widespread resistance of influenza to amantadine and rimantadine has prompted calls for restraint in antiviral use in order to preserve the therapeutic value of these adamantanes as well as newer generation agents.
Amantadine (Symmetrel) has demonstrated a modest benefit on MS fatigue and is much less expensive than modafinil.
The gene sequences of the viruses indicated they were sensitive to the antiviral drugs Tamiflu and amantadine.
If taken early, the antiviral agents amantadine and rimantadine are effective in reducing the severity of influenza A, while zanamivir and oseltamivir are effective in reducing the severity of both influenza A and B.
If you are older or in poor health, your doctor may prescribe amantadine, oseltamivir, or zanamivir if you have been exposed to the flu virus or if you have flu symptoms.
The M2 blocker amantadine is widely used and available without a prescription in some countries, including China, note Yi Guan and Honglin then, both of the University of Hong Kong and Shantou University Medical College in China.
Observational studies strongly suggest that amantadine, rimantadine, and oseltamivir are all effective in reducing spread of influenza during outbreaks in nursing homes (Table).
The World Health Organisation says this year's strain is resistant to cheaper anti- viral drugs amantadine and rimantadine.
Medications should be tapered in the order of those with the highest risk-to-benefit ratio: Anticholinergics should be tapered first, followed by selegiline, amantadine, dopamine agonists, and catechol 0-methyltransferase inhibitors.
Now the appraisal committee will look at a new drug, Tamiflu, which is in the process of being licensed in Europe, and a new formulation of an older drug called amantadine.
Rimantadine and amantadine have been approved for use by adults and children who are 1 year of age and older.