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aminopeptidase |
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| difficile was identified by Gram stain (spore-forming gram-positive
rods) and detection of L-proline aminopeptidase activity (Pro Disc,
Remel, Lenexa, KS, USA) (19).
Additionally, PRAECIS is presenting research on the potential role of
PPI-2458 in melanoma in a poster entitled "Effects of PPI-2458, an
inhibitor of methionine aminopeptidase type-2 on growth of melanoma and
expression of MITF" (Abstract #349). This metalloprotease receptor is widely
divergent from the aminopeptidase N receptor of group 1 CoVs (16) but is
expressed in lung, heart, kidney, and gastrointestinal tissue,
consistent with the pathology of SARS. |
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