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amitriptyline

   Also found in: Medical, Wikipedia 0.09 sec.
am·i·trip·tyl·ine  (m-trpt-ln)
n.
A tricyclic antidepressant drug, C20H23N.

[Perhaps ami(no)- + alteration of trypt(ophan) + -yl + -ine2.]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.amitriptyline - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
tricyclic, tricyclic antidepressant, tricyclic antidepressant drug - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain

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These include the anti-epileptic drugs topiramate (Topamax) and sodium valproate (Depakote), tricyclic antidepressants such as amitriptyline (Elavil) and nortriptyline (Pamelor), beta blockers such as propranolol (Inderal), calcium blockers such as verapamil, and the antihistamine cyproheptadine (Periactin) in children.
These risks were similar among people treated with an SSRI--either fluoxetine (Prozac) or paroxetine (Paxil)--or a tricyclic antidepressant-either amitriptyline or dothiepin.
Some success was reported with the tricyclic antidepressants amitriptyline (4) and nortriptyline, (5,6) but Mihail et al (7) found that trimipramine was not superior to placebo.
 
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