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A tricyclic antidepressant drug, C20H23N, used in the form of its hydrochloride salt.

[Perhaps ami(no)- + alteration of trypt(ophan) + -yl + -ine.]


(ˌæmɪˈtrɪptɪˌliːn; -lɪn)
(Pharmacology) a tricyclic antidepressant drug. Formula: C20H23N
[C20: from amino + tryptamine + methyl + -ine2]


(ˌæm ɪˈtrɪp təˌlin, -ˌlaɪn, -lɪn)

a white crystalline powder, C20H23N, used to treat depression and enuresis.
[1960–65; ami(no)- + tri- + (he)ptyl (see heptane, -yl) + -ine1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.amitriptyline - a tricyclic antidepressant drug (trade name Elavil) with serious side effectsamitriptyline - a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
tricyclic, tricyclic antidepressant, tricyclic antidepressant drug - an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain


n amitriptilina
References in periodicals archive ?
For their study, the researchers designed a large prospective, multi-centre, randomised placebo-controlled trial in which children, ages eight to 17, with IBS, functional abdominal pain or functional dyspepsia were randomised to four weeks of placebo or amitriptyline.
However, while those findings concluded that the use of the antidepressant drug amitriptyline can benefit adults suffering from severe gastrointestinal disorders, a recent study on children shows that the drugs are no more effective than a placebo in treating these conditions.
If it seems the amitriptyline may be a problem, there is another drug, clomipramine, which is approved by the FDA for treating dogs with separation anxiety.
5-50 mg/day) of tricyclic antidepressants (TCAs), such as amitriptyline or doxepin, had a significant effect in reducing pain, depression, fatigue, and sleep problems.
Q I have been given Amitriptyline to help me sleep.
Amitriptyline, fluoxetine, and venlafaxine were selected for the study as respective representative examples of the three most prescribed classes of antidepressant drugs: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and selective serotonin-norepinephrine reuptake inhibitors (SNRIs).
Amitriptyline inhibits the reuptake of noradrenaline and serotonin with similar potency, while the metabolic nortriptyline inhibits the reuptake of noradrenaline to a great degree than serotonin.
But when the engineered mice received the drug amitriptyline, they fended off P.
For example, a reported case (Delilse 1990) involved a 24-year-old female with a history of alcohol and marijuana abuse who used increasing doses of amitriptyline such that she would achieve a "high" characterized by feelings of relaxation, giddiness, and contentment, and eventually confessed that she believed she was "addicted" to amitriptyline.
SSRIs include drugs such as fluoxetine (Prozac) and sertraline (Zoloft), while TCAs include drugs such as desipramine (Norpramin) and amitriptyline (Elavil).
The study concluded on average, amitriptyline was more effective in relieving chronic central neuropathic pain in participants with SCI, and this was particularly true for people with depression.