For their study, the researchers designed a large prospective, multi-centre, randomised placebo-controlled trial in which children, ages eight to 17, with IBS, functional abdominal pain or functional dyspepsia were randomised to four weeks of placebo or amitriptyline
However, while those findings concluded that the use of the antidepressant drug amitriptyline
can benefit adults suffering from severe gastrointestinal disorders, a recent study on children shows that the drugs are no more effective than a placebo in treating these conditions.
If it seems the amitriptyline
may be a problem, there is another drug, clomipramine, which is approved by the FDA for treating dogs with separation anxiety.
5-50 mg/day) of tricyclic antidepressants (TCAs), such as amitriptyline
or doxepin, had a significant effect in reducing pain, depression, fatigue, and sleep problems.
Q I have been given Amitriptyline
to help me sleep.
, fluoxetine, and venlafaxine were selected for the study as respective representative examples of the three most prescribed classes of antidepressant drugs: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and selective serotonin-norepinephrine reuptake inhibitors (SNRIs).
inhibits the reuptake of noradrenaline and serotonin with similar potency, while the metabolic nortriptyline inhibits the reuptake of noradrenaline to a great degree than serotonin.
But when the engineered mice received the drug amitriptyline
, they fended off P.
For example, a reported case (Delilse 1990) involved a 24-year-old female with a history of alcohol and marijuana abuse who used increasing doses of amitriptyline
such that she would achieve a "high" characterized by feelings of relaxation, giddiness, and contentment, and eventually confessed that she believed she was "addicted" to amitriptyline
is one of the major tricyclic antidepressants (TCA) (1).
SSRIs include drugs such as fluoxetine (Prozac) and sertraline (Zoloft), while TCAs include drugs such as desipramine (Norpramin) and amitriptyline
The study concluded on average, amitriptyline
was more effective in relieving chronic central neuropathic pain in participants with SCI, and this was particularly true for people with depression.