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amyloid |
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amyloid [ˈæmɪˌlɔɪd] n 1. (Life Sciences & Allied Applications / Biochemistry) Pathol a complex protein resembling starch, deposited in tissues in some degenerative diseases 2. any substance resembling starch adj starchlike
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| Specifically, using DNAVEC's proprietary Sendai virus vector,
they plan to develop a gene vaccine that can selectively induce the
production of anti-beta amyloid antibodies. Amyloidosis is characterized by an abnormal extracellular
deposition of amyloid in different tissues and organs, where it usually
causes some type of dysfunction. Neutralization of transthyretin reverses the neuroprotective
effects of secreted amyloid precursor protein (APP) in APPSW mice
resulting in tau phosphorylation and loss of hippocampal neurons:
support for the amyloid hypothesis. |
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