Researchers collected samples of cerebrospinal fluid from 208 cognitively normal people, ages 55 to 90, and measured levels of biomarkers for amyloid beta, responsible for the hallmark amyloid plaque
buildups of Alzheimer's disease.
In patients treated up to 24 months in the titration cohort, amyloid plaque
reduction as measured by positron emission tomography (PET) was consistent with the dose- and time-dependent results observed in the fixed-dose cohorts.
According to the researchers, sleep problems accelerate the development of amyloid plaque
in both people without dementia and in those already suffering from dementia.
Aducanumab is thought to target aggregated forms of beta amyloid including soluble oligomers and insoluble fibrils which can form into amyloid plaque
in the brain of AD patients.
These early studies of aducanumab show its effectiveness in removing amyloid plaque
from the brain as well as its potential effect on the slowing of cognitive decline in patients suffering from Alzheimer's disease," Alfred Sandrock, executive vice president and chief medical officer at Biogen, said in a (http://media.
The progression of Alzheimers disease is characterised by the accumulation of amyloid plaque
in the brain.
Researchers at Braincure Biotech prefer the latter approach, considering that the loss of the G protein-coupled receptor 3 (abbreviated GPR3) could reduce the amyloid plaque
accumulation and increase cognitive functions.
The mutation carriers were found to have amyloid plaque
and inflammatory changes almost twenty years before the estimated debut of memory problems.
The progression of AD is characterized by the accumulation of amyloid plaque
in the brain, which is associated with the enzyme BACE.
Alzheimer's disease is characterized by the accumulation of amyloid plaque
in the brain.
Our study shows that both higher levels of HDL - good - and lower levels of LDL - bad - cholesterol in the bloodstream are associated with lower levels of amyloid plaque
deposits in the brain," said study leader professor Bruce Reed, from the University of California at Davis (UC Davis).
The density of amyloid plaque
decreased significantly after day 14.