Acute treatment of normal and ob/ob (leptin-deficient) rats with leptin results in a reduction in anadamide
(AEA) and 2-arachidonoylglycerol (2-AG) levels in the hypothalamus, while the ob/ob obese animals were found to have increased levels of AEA and 2-AG, therefore possibly contributing to overeating in the development of obesity (Di Marzo et al.
We are familiar with similar situations regarding the determination of concentrations of epinephrine, neuropeptide Y, oxytocin, and anadamide
, among other neurohormonal analytes (116).
is only a partial agonist for the CB 1 receptor, and greater efficacy is produced by synthetic derivatives, such as CP55940, which led to the discovery of the CB1 receptor (4).