Grade III (anaplastic) meningiomas are characterized by anaplasia
, brain invasion, and [greater than or equal to] 20 mitoses per 10 HPF or are of the rhabdoid or papillary subtypes (Perry et al.
Nevertheless, a few studies have documented minor his top a tho logical differences between AIDS-associated KS and non-HIV associated KS cases [14-16]: lesional cell mitoses and cellular anaplasia
are surprisingly more common in HIV-negative patients, whereas KS lesions in HIV-positive patients tend to display more extensive dissecting vessels.
Neoplastic cells showed a high degree of anaplasia
, high nucleus-to-cytoplasm ratio, usually one prominent nucleolus, partially condensed chromatin, and high mitotic index.
This behavior is best predicted by the histologic grade, which is determined by 4 factors: mitotic index, degree of cellularity, necrosis when present, and degree of nuclear anaplasia
We theorize that tumor anaplasia
caused malignant myocytes to reexpress CK-MB and cTnT isoforms.
All of these tumor markers in conjunction with lymph-node-positive or lymphnode-negative status combined with the degree of histological anaplasia
or with radiological findings of possible metastases define the stage of the disease or the severity of the malignancy.
The benign nature of this lesion was suggested by the lack of any mitotic activity, anaplasia
, or dysplasia.
Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia
and significant morphologic overlap with small cell carcinoma.
Microscopically, the tumor cells were arranged in diffuse compact trabeculae, with variable degrees of anaplasia
, and increased mitotic activity in the control group.
One isolated focus of perineural invasion by the epithelial component was noted; there was no lymphovascular invasion, nor any necrosis, anaplasia
, or mitosis in the specimen.
1) The term "dedifferentiated" implies that a portion of cells from the chondrosarcoma have degenerated into a high-grade malignant form that is characterized by pleomorphism, anaplasia
, hypercellularity, and increased mitoses.
The tumor specimen had extensive areas of calcification, and there were areas of hypercellularity with zones of necrosis; nuclear anaplasia
and mitoses were evident.