OBJECTIVE: The beneficial effect of the natural compound propionyl-l-carnitine (PLC) on intermittent claudication in patients with peripheral arterial disease is attributed to its anaplerotic
function in ischemic tissues, but inadequate information is available concerning action on the vasculature.
2), which contributes to 50% of the anaplerotic
flux of glutamate into the tricarboxylic acid (TCA) cycle.
Experimental observation suggests that both anaplerotic
reactions and glyoxalate cycle play an important role for the production of tricarboxylic acid (TCA) cycle derived amino acids (aspartate which is a precursor of lysine and glutamate families) (Petersen, et al.
Cramer MD, Schierholt A, Wang YZ, Lips SH (1995) The influence of salinity on the utilization of root anaplerotic
carbon and nitrogen metabolism on tomato seedling.
This effect is most intriguing in light of recent observations demonstrating that the inhibition of electron transport in cancer cells is a lethal insult (39-41), not because of an ensuing energetic catastrophe--cancer cells derive most of their ATP from glycolysis, but because the accumulation of NADH in the mitochondrial matrix inhibits the Krebs cycle and its associated anaplerotic
reactions that support the generation of biomass (42).
Perspective: Emerging evidence for signaling roles of mitochondrial anaplerotic
products in insulin secretion.
Increased lactate concentration is an anaplerotic
effect of alkalaemia (33,34), operating as a feedback loop which buffers pH swings (35,36).