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angiostatin

   Also found in: Wikipedia 0.04 sec.
an·gi·o·stat·in  (nj--sttn)
n.
A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.



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For example, Judah Folkman first envisioned the idea of angiogenesis at the beginning of his career, more than forty years ago, yet neither endostatin nor angiostatin, the potent antiangiogenesis drugs he developed, nor others in this category that have been developed by other researchers, had been approved by the Food and Drug Administration in mid-2004.
Nineteen patients with various cancers received daily intravenous infusions of the drug angiostatin for up to 6 months without showing any serious side effects, says study coauthor Robert L.
The ultimate aim of the endostatin trial, and a separate angiostatin trial expected to begin early next year, is to see whether treating patients with either protein can tip the balance against the tumor.
 
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