It has been implicated in the production of leptin hormone, a potent anorexigenic
adipocyte-derived peptide that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure.
The neuropeptides concerned with feeding behavior are involved in this complex controlling system, of which the anorexigenic
neuropeptide like proopiomelanocortin (POMC) and orexigenic neuropeptide like Neuropeptide Y (NPY) play important roles in the regulation of food intake and energy balance (Bazhan and Zelena, 2013).
The Role of "Mixed" Orexigenic and Anorexigenic
Signals and Autoantibodies Reacting with Appetite Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa.
Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic
effect of leptin.
Several excellent reviews on the topic have recently been published (38, 39), with the balance of data supporting several critical metabolic functions including (a) anorexigenic
action via central nervous system control of feeding behavior, (b) augmented glucose disposal in skeletal muscle via actions on several proteins in the insulin signaling pathway and by increased glucose transporter type 4 translocation, (c) prevention of visceral fat accumulation and decreased lipogenic activity of lipoprotein lipase in adipose tissue, and (d) antiapoptotic effects on pancreatic [beta]-cells.
UGP302, being developed for the treatment of diabetes via a joint venture with Nordic BioScience; oral PTH; and the anorexigenic
The PI3K-AKT, mTOR-p70S6 kinase and AMPK pathways play distinct and critical roles in metabolic regulation, and each pathway is necessary for leptin's anorexigenic
effects in the hypothalamus, which inhibit food intake.
Histamine potentiates leptin and its anorexigenic
For example, in PWS cases leptin levels are increased causing an inability to produce an anorexigenic
effect (Proto et al.
These two energy-monitoring systems interact with insulin, leptin, ghrelin and many of the GI tract-pancreas peptides to express both orexigenic and anorexigenic
peptides, which pass a sensation of hunger or satiety to higher sections of the brain.
An additional safety concern was the possible development of cardiac valve abnormalities, as has occurred with some anorexigenic
The former is comprehensive; it includes up-to-date information on orexigenic and anorexigenic
hormones and cytokines, obesity syndromes and genome-wide searches on obesity yet at the same time it does not neglect social policy or bariatric surgery There is also quite the best summary on nutritional assessment I have ever read, contributed by Khursheed Jeejeebhoy, the doyen of gastroenterological clinical nutrition and former Chief at Toronto General Hospital, known affectionately to generations of trainees as the 'Jeej'.