anti-TNF compound


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Noun1.anti-TNF compound - a class of drugs that block the action of tumor necrosis factor (TNF); used in cases of rheumatoid arthritis because TNF instigates inflammation of the joints
drug - a substance that is used as a medicine or narcotic
Enbrel, etanercept - a genetically engineered anti-TNF compound (trade name Enbrel) consisting of receptors that bind TNF; it is injected twice a week in the treatment of rheumatoid arthritis
infliximab, Remicade - an anti-TNF compound (trade name Remicade) consisting of an antibody directed against TNF; it is given intravenously at one-month to three-month intervals; used in treatment of regional enteritis and rheumatoid arthritis
Arava, leflunomide - an anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synovium
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This includes further developing our R&D capability by way of a key appointment to enhance our clinical expertise and to oversee the human clinical trials of our compounds, including lead anti-TNF compound PN0621, expected to commence Phase I clinical trials in the second quarter of 2007.