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 (ăn′tē-ăn′drə-jən, ăn′tī-)
A substance that inhibits the biological effects of androgenic hormones.
References in periodicals archive ?
The drug exerts its antiandrogenic effects by inhibiting an enzyme in the testosterone synthetic pathway.
2] blockers is that it has weak antiandrogenic activity in both humans and animals, and it also reduces cytochrome P450 pathway metabolism, raising concerns about the potential risks of feminization in males and significant drug interactions.
The findings are consistent with a modest antiandrogenic effect," says Paul Foster, chief of the Toxicology Branch at the
The only diuretic that has been shown to be of benefit in PMS is spironolactone, an aldosterone antagonist with antiandrogenic properties.
Animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP (Boberg et al.
Drospirenone--a spironolactone Analogue--has antiandrogenic and antimineralocorticoid activity.
Some of the most commonly used phthalates have been shown to cause outcomes in rats consistent with antiandrogenic effects, such as impaired spermatogenesis, undescended testes (cryptorchidism), and reduced anogenital distance (Borch et al.
Alternatively, associations might be explained by a combination of antiestrogenic and antiandrogenic effects.
Some PAHs, such as phenanthrene and to a lesser extent fluoranthene, show antiandrogenic effects (Chang and Liao 1987; Vinggaard et al.
BACKGROUND: Phthalates have antiandrogenic effects and may disrupt lipid and carbohydrate metabolism.
The active phthalates disrupt steroidogenesis in fetal rat Leydig cells, and this antiandrogenic effect impairs the normal development of the male reproductive tract (Jones et al.