The drug exerts its antiandrogenic
effects by inhibiting an enzyme in the testosterone synthetic pathway.
2013) and one study showing antiandrogenic
activity (Kitamura et al.
2] blockers is that it has weak antiandrogenic
activity in both humans and animals, and it also reduces cytochrome P450 pathway metabolism, raising concerns about the potential risks of feminization in males and significant drug interactions.
The findings are consistent with a modest antiandrogenic
effect," says Paul Foster, chief of the Toxicology Branch at the
The only diuretic that has been shown to be of benefit in PMS is spironolactone, an aldosterone antagonist with antiandrogenic
Animal data suggest that DiNP may have antiandrogenic
properties similar to those of DEHP (Boberg et al.
Drospirenone--a spironolactone Analogue--has antiandrogenic
and antimineralocorticoid activity.
Some of the most commonly used phthalates have been shown to cause outcomes in rats consistent with antiandrogenic
effects, such as impaired spermatogenesis, undescended testes (cryptorchidism), and reduced anogenital distance (Borch et al.
Alternatively, associations might be explained by a combination of antiestrogenic and antiandrogenic
Some PAHs, such as phenanthrene and to a lesser extent fluoranthene, show antiandrogenic
effects (Chang and Liao 1987; Vinggaard et al.
BACKGROUND: Phthalates have antiandrogenic
effects and may disrupt lipid and carbohydrate metabolism.
The active phthalates disrupt steroidogenesis in fetal rat Leydig cells, and this antiandrogenic
effect impairs the normal development of the male reproductive tract (Jones et al.