Once identified, these may then be further improved using the company's highly efficient process for fine-tuning of antibodies
and other proteins to increase their activity, called EvoGene(TM) Optimisation.
The objectives of this study were to assess the seroprevalence of antibodies
to CHIKV in a sample of pregnant women and the kinetics of transplacentally transferred antibodies
That's how monoclonal antibodies
--as well as polyelonal antibodies
, which target multiple surface proteins--can knock out some immune cells to prevent rejection of transplanted tissues.
Subsequently, Kirin and Hematech have progressed to developing cows that can efficiently produce human antibodies
Because immunologic tolerance is incomplete, it is not unexpected that IgG antibodies
specific for food proteins are found in normal subjects with no signs or symptoms of food allergy (Barnes 1995; Barnes et al.
She agrees with her colleagues that most antibodies
against HIV are not effective.
Researchers from a number of laboratories have published results of preclinical experiments showing the role of anti-CD4 antibodies
in slowing or halting the course of autoimmune disease in animal models.
VelocImmune is the centerpiece of Regeneron's suite of technologies for the discovery and development of fully human antibodies
," said George D.
Traditional methods of making antibodies
to proteins require that the protein of interest be produced and purified in relatively large quantities prior to injection for antibody production.
Thus, typical HA-specific antibodies
neutralize viral infectivity and fully protect against infection when they are present at sufficient concentration in the lining fluid of the respiratory tract, and typical NA-specific antibodies
inhibit the release of newly formed virus from infected host cells and thus limit the spread and shedding of virus during infection.
They determined that the antibodies
that triggered arthritis target an enzyme called glucose-6-phosphate isomerase, or GPI.
This observation suggests that it may be possible to treat human patients with PDL's antibodies
once every two weeks or even less frequently, compared to every day or two for first-generation monoclonal antibodies
, which were derived from mice.