8,129,330 B2 titled "Polymer Conjugates with Decreased Antigenicity
, Methods of Preparation and Uses Thereof.
dagger]) Sites associated with antigenicity
are indicated in boldface (not comprehensive) (11).
In this study, the decreased antigenicity
made the heterologous BAMG transplants feasible without immunosuppression.
While several techniques have been evaluated for their potential to preserve antigenicity
of slide-mounted sections, a universal preservation protocol has yet to be identified.
When bovine a-casen and [beta]-lactoglobulin in milk were used, the allergenicity and antigenicity
of irradiated proteins were changed by different slopes of the inhibition curves.
The molecules are relatively simple and thus have low antigenicity
and potential for hypersensitivity.
It is very important to avoid Rh immunization due to blood transfusion because of strong antigenicity
of Rh system.
THR-100 has also demonstrated superior efficacy to strepto-kinase with reduced antigenicity
, or allergic reaction, a common side effect in streptokinase therapy.
5) Therefore, the proposed therapeutic niche in gout is limited to months of treatment with recombinant uricase preparations that are modified to provide a long duration of action and less antigenicity
, with the clinical indication being primarily reduction of macroscopic destructive tophus burden in carefully selected patients.
Three (M1, M6, and M7) of these 5 mAbs exhibited slight binding to NT3 (amino acids 119-213), further confirming the antigenicity
of the region of amino acids 68-213.
The number of alleles in the ABO and Rh blood group systems, and the low antigenicity
of all but the D antigen in the Rh system, make it relatively easy to supply blood in virtually unlimited quantities to patients requiring hemotherapy.
For influenza A viruses, modifications of N-linked glycosylation sites in the globular head of the hemagglutinin protein have been linked to changes in virulence, antigenicity
, receptor-binding preference, fusion activity, and immune evasion (4).