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antiglobulin
(redirected from antiglobulin test)

   Also found in: Medical, Legal, Financial, Encyclopedia, Wikipedia 0.01 sec.
antiglobulin [ˌæntɪˈglɒbjʊlɪn]
n
(Medicine) a serum containing an antibody specific to an immunoglobulin


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Current guidelines for HS diagnosis include family history, splenomegaly, abnormal CBC indices [spherocytes identification; increase in MCHC (mean corpuscular hemoglobin concentration)], reticulocytes, and RDW (red cell distribution width); and decrease in Hb (hemoglobin) and MCV (mean cell volume), a negative direct antiglobulin test, increased bilirubin, and reticulocytosis.
Results of the patient's direct antiglobulin test (DAT) were strongly positive using broad-spectrum reagents and anti-immunoglobulin G (IgG) and C3 antibodies.
Infants at high risk of severe hyperbilirubinemia are those with jaundice in the first 24 hours, predischarge bilirubin levels in the high-risk zone, blood group incompatibility by positive DAT (direct antiglobulin test or the direct Coombs test) or hemolytic disease, gestational age between 35 to 36 weeks, a previous sibling with phototherapy treatment, and cephalohematoma.
 
 
 
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