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antihypertensive drug |
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11) Warfarin (Coumadin ([parallel])), digoxin, and mibefradil (an antihypertensive drug now removed from the market) have been reported to interact with statins in cases of rhabdomyolysis. Notable examples include nerve damage among individuals homozygous for some variants of the N-acetyltransferase 2 gene ("slow acetylators") given isoniazid as an antituberculosis therapy, hemolytic anemia among glucose 6-phosphate dehydrogenase-deficient patients given aminoquinoline antimalarial drugs, and varied rates of biotransformation of debrisoquine, an antihypertensive drug, due to genetic variation at the CYP2D6 locus (Weber 1997). The risk of myocardial infarction associated with antihypertensive drug therapies. |
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