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antimetabolite

   Also found in: Medical, Encyclopedia, Wikipedia 0.03 sec.
an·ti·me·tab·o·lite  (nt-m-tb-lt, nt-)
n.
A substance that closely resembles an essential metabolite and therefore interferes with physiological reactions involving it.
anti·meta·bolic (-mt-blk) adj.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis


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Certain conventional chemotherapies, such as the antimetabolite gemcitabine, exert their anticancer activity at the S-phase of the cell cycle.
CYCLACEL'S CYC202 INDUCES CANCER CELLS TO COMMIT SUICIDE by Worldwide Biotech
Surgeons began to find success with purine antimetabolites and with antilymphocytic globulin, developed by an upstart ex-football player named John Najarian.
On being a happy surgeon by McQuarrie, Donald G. / Ear, Nose and Throat Journal
He starts with Paul Ehrlich's antitreponemal arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.
The Elusive Magic Bullet: The Search for the Perfect Drug by Zuger, Abigail / Emerging Infectious Diseases
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