antimetabolite


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to antimetabolite: methotrexate

an·ti·me·tab·o·lite

 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
n.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.

antimetabolite

(ˌæntɪmɪˈtæbəˌlaɪt)
n
(Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatment

an•ti•me•tab•o•lite

(ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)

n.
any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers.
[1940–45]
an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
References in periodicals archive ?
45) The addition of antimetabolite mitomycin C to LES, applied after excimer laser ablation at a concentration of 0.
A cytotoxic antimetabolite is used today to prevent closure of the flap, however, the treatment is associated with significant side effects.
Rosenbaum will quickly switch to an antimetabolite, with methotrexate his top choice.
The ability of CD to convert nontoxic 5FC into toxic 5FU antimetabolite and its absence in mammalian cells has been exploited in enzyme-prodrug gene therapy and shown to control tumour growth (Hamaji et al.
Methotrexate is an antimetabolite that penetrates the blood brain barrier when given in high doses intravenously.
Prospective, randomized, controlled trials are currently underway to formulate evidence-based algorithms for the initiation of antimetabolite therapy in IBD.
It compared the continuation of cyclophosphamide after disease remission to "step-down" to an antimetabolite with fewer side effects, azathioprine.
ALLs with hyperdiploidy with >50 chromosomes in children are highly sensitive to antimetabolite drugs and have a complete remission rate approaching 100% with an ~80% long-term disease-free survival (9).
Azathioprine is the generic equivalent to Imuran, an immunosuppressive antimetabolite manufactured by Glaxo Wellcome Inc.